001), whereas induction PF followed by RT was not better than treatment with RT alone (HR, 1.26 95% CI, 0.88 to 1.82 P =. ![]() ![]() Concomitant cisplatin/RT significantly improved the larynx preservation rate over induction PF followed by RT (HR, 0.58 95% CI, 0.37 to 0.89 P =. Overall survival did not differ significantly, although there was a possibility of worse outcome with concomitant relative to induction chemotherapy (HR, 1.25 95% CI, 0.98 to 1.61 P =. 02 concomitant chemotherapy v RT alone: HR, 0.78 95% CI, 0.78 to 0.98 P =. Both chemotherapy regimens significantly improved LFS compared with RT alone (induction chemotherapy v RT alone: hazard ratio, 0.75 95% CI, 0.59 to 0.95 P =. Median follow-up for surviving patients is 10.8 years. Five hundred twenty patients were analyzed.
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